en تخصصي Special پژوهشي Research <strong>Background</strong>: Self-care of adolescents with congenital heart disease (CHD) is one of the challenges of the health care system. CHD is a common chronic disease that affects the quality of life (QoL) and self-efficacy of adolescents. This study compares the effectiveness of self-care education by face-to-face method and video clip (VC) on self-efficacy and QoL in late adolescents with CHD.<br> <strong>Methods</strong>: This research was a non-randomized clinical trial. A total of 111 late adolescents aged 18 to 21 years with CHD referred to Rajaie Cardiovascular, Medical, and Research Center in Tehran, Iran, were recruited by convenience sampling and non-randomly assigned to either control, face-to-face (F2F), or VC groups (37 subjects in each group). The F2F group participated in two educational sessions (each lasted 35-45 minutes) with an interval of one week, and the VC group received a 90-minute video to watch at home. The study data were collected before (T1) and two months after the intervention (T2), using the Generalized Self-Efficacy (GSE) scale and World Health Organization&rsquo;s Quality of Life Questionnaire (WHOQOL-BREF) and analyzed in SPSS version 19 software using the Chi-square test, Fisher test, paired t test, Scheff&eacute; test, and ANOVA. The significance level was set at P<0.05.<br> <strong>Results</strong>: Before the intervention, demographic variables, self-efficacy, and QoL were not significantly different in the three groups. The self-efficacy significantly increased in the F2F (P<0.004) and VC groups (P<0.031) at T2. Furthermore, QoL dimensions significantly improved in the F2F and VC groups (P<0.05), except for the environment dimension (P>0.05).<br> <strong>Conclusion</strong>: Self-care education through F2F and VC significantly affects the self-efficacy and QoL of late adolescents. Such educational programs can greatly reduce the possible complications of the disease by empowering this group. Self-care education, Congenital heart disease, Adolescents, Self-efficacy, Quality of life 69 78 http://jccnc.iums.ac.ir/browse.php?a_code=A-10-480-1&slc_lang=en&sid=1 Parisa Hasannezhad parisa.hasannezhad@yahoo.com 10031947532846008806 10031947532846008806 No Department of Pediatric Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Sedigheh Khanjari sed.khanjari@gmail.com 10031947532846008807 10031947532846008807 No Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Akbar Nikpajouh dr.nikpajouh@gmail.com 10031947532846008808 10031947532846008808 No Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra Hasannezhad Hasannejad.205@gmail.com 10031947532846008809 10031947532846008809 No Social Research Center, Karaj Municipality, Karaj, Iran. Hamid Haghani haghani511@yahoo.com 10031947532846008810 10031947532846008810 No Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Fahimeh Sabeti sabetifa@yahoo.com 10031947532846008811 10031947532846008811 Yes Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.