en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;"><strong>Background</strong>: Hospitalized patients with COVID-19 may experience emotional problems and respiratory discomfort during mechanical ventilation. This study aimed to evaluate the effects of music therapy on respiratory comfort, anxiety, and depression among patients with COVID-19 under noninvasive mechanical ventilation.<br> <strong>Methods</strong>: It was a randomized clinical trial. The study subjects were 64 patients requiring noninvasive mechanical ventilation (NIV) who were selected from the COVID-19 intensive care unit (ICU) of Ali ibn Abi Talib Hospital, Rafsanjan City, Iran. They were randomly allocated to the intervention (n=32) and control (n=32) groups. The intervention group received 30 minutes of daily light music by an MP3 player and a JBL headphone for 4 consecutive days, and the control group only used headphones. The data were collected by the hospital anxiety and depression scale and a visual analog scale before and 4 days after the intervention. The SPSS software, version 16 was employed for data analysis through the chi-square, independent sample, and paired-samples t-tests at a significance level P<0.05.&nbsp;<br> <strong>Results</strong>: The groups did not significantly differ regarding the pre-test mean scores of respiratory comfort, anxiety, and depression before intervention (P>0.05). The mean scores of respiratory comfort, anxiety, and depression significantly changed in the intervention group (P<0.05), but no significant changes were seen in the control group (P>0.05). Between-group differences respecting the post-test mean scores of these variables were also significant (P<0.05).&nbsp;<br> <strong>Conclusion</strong>: Thirty minutes of daily music therapy for 4 days is effective in reducing anxiety and depression and improving respiratory comfort among patients with COVID-19 under noninvasive mechanical ventilation.</span></span></span></div> Music, Anxiety, Depression, Respiratory comfort, COVID-19 207 214 http://jccnc.iums.ac.ir/browse.php?a_code=A-10-518-1&slc_lang=en&sid=1 Reyhaneh Hassan Shahi 10031947532846009674 0009-0003-1689-9639 No Department of Medical Surgical Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Fatemeh Hosseini hossini1389@yahoo.com 10031947532846009675 10031947532846009675 Yes Department of Community Health Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ali Akbari 10031947532846009676 10031947532846009676 No Department of Medical Surgical Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ahmadreza Reza Sayadi 10031947532846009677 10031947532846009677 No Department of Psychiatric Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Maryam Shahabi Nedjad 10031947532846009678 10031947532846009678 No Department of Medical Surgical Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.