en تخصصي Special پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>: Multiple sclerosis (MS) represents the most prevalent progressive neurological disorder among young individuals globally. Patients diagnosed with MS often experience a diverse array of psychological challenges. The current study sought to explore the correlation between spiritual wellbeing and fatigue and depression in individuals with MS who referred to the Tehran MS Association, Tehran City, Iran, in 2024.&nbsp;<br> <strong>Methods</strong>: This research employed a cross-sectional, descriptive-correlational design. The statistical population comprised individuals diagnosed with MS who sought assistance from the Tehran MS Association. From this population, 200 participants were selected through continuous sampling in accordance with established inclusion criteria. Data collection instruments included a demographic and disease characteristics questionnaire, the fatigue severity scale (FSS), the Beck depression inventory II (BDI-II), and the Paloutzian and Ellison spiritual wellbeing scale (SWBS). The data analysis was conducted using SPSS version 27, employing both descriptive and inferential statistical methods, including the Pearson correlation coefficient, independent t-test, and analysis of variance. The significance level for all tests was set at 0.05.<br> <strong>Results</strong>: The Mean&plusmn;SD total scores for fatigue, depression, and spiritual health among the participants were 48.33&plusmn;14.52, 19.11&plusmn;13.04, and 92.41&plusmn;25.09, respectively. Statistical analysis revealed a significant negative correlation between fatigue and spiritual health (r=-0.294, P<0.001). Additionally, a significant negative correlation was found between depression and spiritual health (r=-0.650, P<0.001).<br> <strong>Conclusion</strong>: The results of this study indicate an inverse relationship between spiritual wellbeing and the prevalent issues of fatigue and depression among individuals diagnosed with MS. Consequently, it is advisable to incorporate strategies that focus on enhancing spiritual wellbeing, as this may significantly alleviate the mental health challenges faced by these individuals.</span></span></span></div> Spiritual health, Fatigue, Depression, Multiple sclerosis (MS), Quality of life (QoL) 47 58 http://jccnc.iums.ac.ir/browse.php?a_code=A-10-906-1&slc_lang=en&sid=1 Mahnaz Seyedoshohadaee Saydshohadai@yahoo.com 100319475328460014273 100319475328460014273 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Mehrabi mehrabifateme0@gmail.com 100319475328460014274 100319475328460014274 Yes Department of Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Shima Haghani shima_haghani@yahoo.com 100319475328460014275 100319475328460014275 No Nursing Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.