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Hartono M, Sunarto S, Supriyo S, Sudirman S, Inayah M. The Effect of Red Ginger Extract, Klanceng Honey, and Their Combination on Blood Sugar, Cholesterol, and Blood Viscosity of Patients With Diabetes Mellitus. JCCNC 2025; 11 (3) :249-260
URL: http://jccnc.iums.ac.ir/article-1-697-en.html

Background: The prevalence of diabetes mellitus (DM) is increasing, especially in low- and middle-income countries. DM leads to changes in blood sugar, cholesterol levels, and blood viscosity. Therefore, seeking alternative medicine with active ingredients to lower blood sugar levels, cholesterol, and blood viscosity is crucial. This study investigated the effects of red ginger extract and Klanceng honey on blood sugar levels, cholesterol, and blood viscosity in diabetic patients with hyperglycemia and hypercholesterolemia in Pekalongan City, Central Java, Indonesia. 
Methods: This quasi-experimental study employed a pre-test, post-test design. The subjects were diabetic patients with hyperglycemia and hypercholesterolemia. Thirty participants were randomly assigned to three groups (ginger group, honey group, and combination of ginger and honey group), each with 10 subjects. The dose of red ginger extract was 60 mg/d, while the dose of Klanceng honey was 1 mL/kg/d. The subjects consumed 3-4 capsules of ginger extract, 15-20 mL of Klanceng honey (based on their weight), or a combination of ginger and Klanceng three times a day for 7 consecutive days. SPSS software, version 22 was used to analyze the data. Bivariate and mathematical general linear models (GLM) were applied with a significance level of 0.05.
Results: The combination of red ginger and Klanceng honey significantly reduced blood sugar levels (P=0.001; 95% CI, 10.20%, 28.80%), cholesterol (P<0.001; 95% CI, 9.44%, 25.16%), and blood viscosity (P< 0.001; 95% CI, 1.63%, 3.17%) compared to giving Klanceng honey or red ginger alone. A mathematical GLM analysis, controlling for pre-treatment blood values, showed that the combination of red ginger and Klanceng honey reduced blood sugar by 6.89% compared to Klanceng honey and 0.01% compared to red ginger alone. It also lowered cholesterol by 4.00% compared to Klanceng honey and 1.50% compared to red ginger alone. The combination of red ginger and Klanceng honey also reduced viscosity by 3.98% compared to Klanceng honey and by 1.53% compared to red ginger alone.
Conclusion: The combination of red ginger extract and Klanceng honey was more effective in reducing blood sugar, cholesterol, and blood viscosity than Klanceng honey and red ginger extract. People with hyperglycemia and hyperlipidemia may use the combination of red ginger extract and Klanceng honey to regulate blood sugar, cholesterol, and viscosity. Healthcare providers may recommend this complementary therapy for patients who benefit from it. Further studies with larger sample sizes and longer treatment periods may be useful to obtain more precise results.