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JCCNC 2025, 11(1): 0-0 |
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Hadipour S, Amini L, Afshar B, Ghasemi A, Haghani H, Sadeghi H A S et al . Effect of Oral Cinnamon Extract on the Metabolic and Hormonal Status of Women with Polycystic Ovary Syndrome: A Blinded Randomized Controlled Clinical Trial. JCCNC 2025; 11 (1)
URL: http://jccnc.iums.ac.ir/article-1-626-en.html
URL: http://jccnc.iums.ac.ir/article-1-626-en.html
Sanam Hadipour1 
, Leila Amini2 , Bahare Afshar * 1, Afsaneh Ghasemi3 , Hamid Haghani4 , Homa Avval Shahr Sadeghi5 , Shayesteh Jahanfar6
, Leila Amini2 , Bahare Afshar * 1, Afsaneh Ghasemi3 , Hamid Haghani4 , Homa Avval Shahr Sadeghi5 , Shayesteh Jahanfar6
1- Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
2- Nursing Care Research Center (NCRC), Iran University of Medical Sciences, Tehran, Iran and Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
3- Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
5- Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
6- Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, USA.
2- Nursing Care Research Center (NCRC), Iran University of Medical Sciences, Tehran, Iran and Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
3- Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
5- Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
6- Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, USA.
Abstract: (23 Views)
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of reproductive age. The aim of this study was to investigate the effect of oral capsules of cinnamon extract on the metabolic profile and hormonal status of women with PCOS.
Methods: This blinded randomized clinical trial was performed on 66 women with PCOS referred to the gynecology and infertility clinics in Tehran, Iran; 2016 - 2017. Eligible women were randomly allocated into intervention (n=33) and placebo (n=33) groups. The oral capsule of three grams’ cinnamon extract was taken once a day for 12 consecutive weeks by the intervention group and the placebo capsule was given in the same way to the control group. Before and 12 weeks after starting the intervention, blood tests were performed to measure fasting blood sugar, fasting insulin, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, total testosterone, and sex hormone binding globulin. The student t-test, paired t-test, chi-square and ANCOVA were used to compare groups using SPSS v. 16 software. A p-value of less than 0.05 was considered significant.
Results: The results showed that consumption of cinnamon extract only leads to a significant decrease in total testosterone level compared to placebo (P=0.001), and has no significant effect on fasting blood sugar, fasting insulin, triglyceride, total cholesterol, low-density and high-density lipoprotein cholesterol, sex hormone binding globulin, and free androgen index.
Conclusion: our study revealed that cinnamon extract at a dose of 3 grams per day (3g/day) for twelve consecutive weeks could decrease total testosterone in women with PCOS, and had no significant effects on metabolic and hormonal indicators in these women. Nevertheless, it is suggested that more studies be conducted with a larger sample size and the use of various doses of cinnamon.
Methods: This blinded randomized clinical trial was performed on 66 women with PCOS referred to the gynecology and infertility clinics in Tehran, Iran; 2016 - 2017. Eligible women were randomly allocated into intervention (n=33) and placebo (n=33) groups. The oral capsule of three grams’ cinnamon extract was taken once a day for 12 consecutive weeks by the intervention group and the placebo capsule was given in the same way to the control group. Before and 12 weeks after starting the intervention, blood tests were performed to measure fasting blood sugar, fasting insulin, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, total testosterone, and sex hormone binding globulin. The student t-test, paired t-test, chi-square and ANCOVA were used to compare groups using SPSS v. 16 software. A p-value of less than 0.05 was considered significant.
Results: The results showed that consumption of cinnamon extract only leads to a significant decrease in total testosterone level compared to placebo (P=0.001), and has no significant effect on fasting blood sugar, fasting insulin, triglyceride, total cholesterol, low-density and high-density lipoprotein cholesterol, sex hormone binding globulin, and free androgen index.
Conclusion: our study revealed that cinnamon extract at a dose of 3 grams per day (3g/day) for twelve consecutive weeks could decrease total testosterone in women with PCOS, and had no significant effects on metabolic and hormonal indicators in these women. Nevertheless, it is suggested that more studies be conducted with a larger sample size and the use of various doses of cinnamon.
Keywords: Herbal medicine, Polycystic ovary syndrome (PCOS), Testosterone, Androgen, Cholesterol
Type of Study: Research |
Subject:
Special
Received: 2024/06/18 | Accepted: 2024/09/3 | Published: 2025/01/1
Received: 2024/06/18 | Accepted: 2024/09/3 | Published: 2025/01/1
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